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Showing results 51 to 60 of 155046

  1. Modulating the expression and activity of the nuclear import protein, Karyopherin β1, in cancer cells
    Carden, Sarah, 2017-08-16T12:32:41Z, University of Cape Town
    Cancer is primarily a disease of disordered gene expression; the dysregulation of thousands of different genes has been associated with the progression of many types of cancer. Previous research from our laboratory aimed at identifying genes differentially expressed in cervical cancer compared to no ...
  2. The impact of EPHA2 polymorphism on KSHV infectivity and KS prevalence among HIV/AIDS patients in South Africa
    Blumenthal, Melissa Jayne Walcott, 2017-08-16T12:32:46Z, University of Cape Town
    Kaposi"s Sarcoma (KS) is the most common Acquired Immune Deficiency Syndrome (AIDS)-related malignancy globally and is of particular significance in sub-Saharan Africa where, due to the Human Immunodeficiency Virus (HIV) epidemic, KS is the cause of significant morbidity and mortality. The oncogenic ...
  3. Agent-based model of the market penetration of a new product
    Magadla, Thandulwazi, 2017-08-16T12:33:14Z, University of Cape Town
    Includes bibliographical references. ...
  4. Locus-coeruleus norepinephrine system function in a developmental animal model of schizophrenia: the socially isolated rat
    Atmore, Katherine H, 2017-08-16T12:33:48Z, University of Cape Town
    Introduction: Schizophrenia is a chronic, debilitating mental disorder characterised by positive, negative and cognitive symptoms. Current treatment regimens fail to adequately address the cognitive and negative symptoms of the disorder. Social isolation rearing (SIR) is a well-established developme ...
  5. Outcomes of children transferring out of Red Cross War Memorial Children"s Hospital HIV cohort using linkage to the National Health Laboratory Service Data
    Arowosegbe, Oluwaseyi, 2017-08-16T12:34:16Z, University of Cape Town
    Background and Rationale: Paediatric antiretroviral (ART) care in the Western Cape Province (WCP) has evolved following South Africa"s (SA) massive roll-out of antiretroviral therapy in 2004 in response to the country"s human immunodeficiency virus (HIV) epidemic. Decentralization of paediatric ART ...
  6. Understanding the dignity experience and exploring the impact of dignity therapy and guided imagery on patients with advanced disease - a South African perspective
    Balbadhur, Raksha, 2017-08-16T12:34:23Z, University of Cape Town
    Objectives: This study was conducted to understand the dignity experience of patients with advanced disease from diverse socio-economic and cultural backgrounds in a South African context. In addition, the psychotherapeutic interventions, Dignity Therapy and Guided Imagery (focused on intrinsic dign ...
  7. The cost-effectiveness of influenza vaccination of pregnant woman in the South African public healthcare setting
    Leong, Trudy Desirie, 2017-08-15T12:35:26Z, University of Pretoria
    Background: International analyses suggest that routine maternal vaccination with seasonal trivalent influenza vaccine is cost-effective, but few studies have been done in middle- to low- income countries. Method: A decision-tree analysis was modelled for the South African public healthcare setting ...
  8. Effect of in vitro simulated gastro-duodenal digestion on the antioxidant and anti-inflammatory activity of South Africa Fynbos honey
    Magoshi, Innocentia Botlhale, 2017-08-15T12:35:28Z, University of Pretoria
    Honey has been shown to have bioactivity. Fynbos (FB) honey was investigated for its bioactivity as this vegetation type is from a unique bio diverse region in the Cape Floristic Kingdom. Six FB and one medical grade Manuka (MAN) UMF 15+ honeys that were of quality grade (Codex Alimentarius) were us ...
  9. Characterization of efflux pumps genes involved in second-line drug resistance of tuberculosis
    Malinga, Lesibana Anthony, 2017-08-15T12:35:28Z, University of Pretoria
    In this study, we used molecular and proteomic methods to detect novel changes within drug-resistant tuberculosis (TB) strains. Our goal was to detect changes within efflux pump (EP) genes of extensively drug resistant (XDR-TB) strains using genomic and transcriptomic methods. We firstly sequenced m ...
  10. Investigating the areas of delay associated with prolonged length of stay in an emergency department in a tertiary hospital in Gauteng
    Mashao, Kapari Constance, 2017-08-15T12:35:29Z, University of Pretoria
    Background: Prolonged length of stay in an emergency department, which affects quality patient care and patient outcomes negatively, is a worldwide problem. Aim: The aim of this study was to describe associated areas of delay in the emergency department and also to investigate factors influencing pr ...